BIOLOGICAL ACTIVITY OF QUERCETIN-3-O-GLUCOSIDE, A KNOWN PLANT FLAVONOID

© 2009 Seyed Mehdi Razavi*^#, Saber Zahri*, Gholamreza Zarrini**, Hossein Nazemiyeh***, Sariyeh  Mohammadi*

^#E-mail: [email protected]

*Department of Biology, Faculty of Sciences, University of Mohaghegh-Ardabili, Ardabil, Iran;
**Depatrment of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran;
***Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medicinal Sciences, Tabriz , Iran

Received: September 19, 2008; in final from: October 14, 2008

Abstract. Cytotoxic, phytotoxic, antimicrobial and antioxidant effects of quercetin 3-O-glucoside (Q3G) isolated by HPLC from aerial parts of Prangos ferulaceae was studied by MTT assay, lettuce germination assay, disk diffusion and DPPH method. Our results showed that Q3G exhibits high antioxidant effect with RC₅₀ of 22 μg/mL, it has low cytotoxicity and no antibacterial effects. Q3G exhibits high phytotoxic effect with IC₅₀ value of 282.7 μg/ml, as well. It is assumed that Q3G does not play a defense role in plants and it may act as an allelopatic agent.

Key words: quercetin 3-O-glucoside, cytotoxic, phytotoxic, antioxidant

Биоорг.химия 2009, 35 (3): 414-416