SYNTHESIS OF SELENIUM-CONTAINING AMINO ACID ANALOGUES AND THEIR BIOLOGICAL STUDY

© 2011 Sh. H. Abdel-Hafez^#*^,**, H. A. Saad*^,***, M. R. E. Aly*^,****

^#Phone: 00966 552453944; e-mail: [email protected]; [email protected]

*Chemistry Department, Faculty of Science, Taif University, 888, Alhawiya, Taif University, Taif, Kingdom of Saudi Arabia;
**Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt;
***Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt;
****Chemistry Department, Faculty of Science, Port Said University, Egypt

Received November 29, 2010; in final form, December 29, 2010

Synthesis of selenium-containing amino acid analogues is described. These compounds were prepared in a concise and short synthetic route in good yields by nucleophilic substitution reaction of pyridineselenol and quinolineselenol derivatives with N-phthaloylglycyl chloride followed by hydrazinolysis. The newly synthesized compounds were screened against different strains of bacteria and fungi.

Key words: pyridineselenol; quinolineselenol; amino acid; anti-bacterial activities; anti-fungal activities.