SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL BENZO[F]COUMARIN COMPOUNDS

©2012 Remon. M. Zaki^#, Yasser A. Elossaily, Adel. M. Kamal El-Dean

^#E-mail: [email protected]

Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt

Received 17.11.2011 in final form 18.01.2012

Abstract. The acetyl benzo[f]coumarin condensed with phenyl hydrazine to afford the corresponding phenyl hydrazone which cyclized into the pyrazolyl benzocoumarin under Vilsmeier reaction conditions. The pyrazolylaldehyde was used as starting material for synthesis of other heterocyclic compounds containing pyrazolylbenzocoumarin moiety. The ethyl benzo[f]coumarin carboxylate were subjected to react with other reagents to synthesize thiazolidinyl and oxadiazolyl derivatives attached to benzocoumarin system. Some of novel synthesized compounds showed highly antibacterial and antifungal activities.

Keywords: acetylbenzo[f]coumarin, pyrazolylbenzocoumarin, bromoacetylbenzo[f] chromenone, synthesis, anti-microbial activity.

Биоорг.химия 2012, 38 (6): 721-728