SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL ISOXAZOLO[4,3-e]INDOLES AS ANTIBACTERIAL AGENTS

Mehdi Pordel*^#, Amin Abdollahi, Bahareh Razavi

^#Tel.: 0098-0511-8414182; fax: 0098-0511-8424020; e-mail: [email protected]

Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Received July 30, 2012; in final form August 6, 2012

Abstract. The synthesis of a new series of 8-bromo-6-alkyl-1-aryl-6H-isoxazolo[4,3-e]indole derivatives is described. All the newly synthesized compounds were screened for their antibacterial activity against Escherichia coli HB101, Staphylococcuse aureus pathogens (methicillin resistant S. aureus and methicillin susceptible S. aureus), Pseudomonas aeruginosa, and Bacillus subtilis; also MIC values of these compounds were determined.

Keywords: Isoxazolo[4,3-e]indole; Antibacterial agents; Staphylococcus aureus, MIC