A GREEN SYNTHETIC APPROACH TO THE SYNTHESIS OF SCHIFF BASES FROM 4-AMINO-2-THIOXO-1,3-DIAZASPIRO[5.5]UNDEC-4-ENE-5-CARBONITRILE AS POTENTIAL ANTI-INFLAMMATORY AGENTS

© 2014 Sh. A. Abdel-Mohsen, E. M. Hussein^#

^#E-mail: [email protected]

Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71516 Egypt

Recevied November 27, 2013; in final form, December 24, 2013

A green, novel, rapid, and efficient protocol is developed for the synthesis of various Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile using ammonium chloride as a very inexpensive and readily available reagent in refluxing ethanol. High yields, easy work-up, and short reaction times are advantages of this environmentally benign procedure. The prepared compounds were screened for their antiinflammatory activity “at a dose of 10 mg/kg body weight”, which revealed promising activities relative to indomethacin used as a reference standard in this study.

Keywords: green synthesis, Schiff bases, anti-inflammatory, rapid procedure, 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile

Биоорг. химия 2014, 40 (3): 370-376