ANDROGENIC-ANABOLIC ACTIVITIES OF SOME NEW SYNTHESIZED STEROIDAL PYRANE, PYRIDINE AND THIOPYRIMIDINE DERIVATIVES

Mohamed M. Abdalla*, Abd El-Galil E. Amr**^, ***^{, #}, Mohamed A. Al-Omar**, Azza A. Hussain****, And Mohamed S. Amer****

^#E-mail: [email protected]

*Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt;
**Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;
***Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt;
**** Chemistry Department, Faculty of Science, Zagazige University, Zagazige Egypt

Received January 28, 2014; in final form, March 3, 2014

In continuation of our previous work, fused steroidal derivatives with pyrane, pyridine, pyrimidine moieties were synthesized and evaluated as androgenic-anabolic agents. Some of the newly synthesized compounds are exhibited pronounced androgenic-anabolic activities.

Keywords: Steroidal derivatives, pyranes, pyridines, pyrimidines, androgenic-anabolic activities.

Биоорг. химия 2014, 40 (5): 618-628