ANTI-INFLAMMATORY ACTIVITIES OF SOME NEWLY SYNTHESIZED PYRIDINYL- AND INDAZOLYL BENZAMIDE DERIVATIVES

© 2015 Azza A. Hussain^{1, #}, Mohamed M. Abdulla², Abd El-Galil E. Amr^{3, 4}, Mohamed A. Al-Omar³, Ahmed F. A. Shalaby¹

^#E-mail: [email protected]

¹Chemistry Department, Faculty of Science, Cairo University, Egypt;
²Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt;
³Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;
⁴Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt

Received 27.02.2014; in final form 29.04.2014

A series of substituted (pyridine-4-yl)phenyl-2-methoxybenzamide and their derivatives were prepared and screened for their anti-inflammatory activities. Initially the acute toxicity of the compounds was assayed via the determination of their LD₅₀. Some of the newly synthesized compounds exhibited better pharmacological and biological responses than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences.

Keywords: 5-chloroanisic acid, aldehydes, N-substituted benzamides, anti-inflammatory activities