SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL FUSED THIAZOLO[3,2-A]PYRIMIDINES AS POTENTIAL ANALGESIC AND ANTI-INFLAMMATORY AGENTS

© 2015 Nagy M. Khalifa^{a, b, #}, Mohamed A. Al-Omar^a, Abd El-Galil E. Amr^{a, c}, Ayman R. Baiuomy^{d, e}, and Rehab F. Abdel-Rahman^d

^#E-mail: [email protected]

^aPharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451 Saudi Arabia;
^bDepartment of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Cairo, Dokki, 12622 Egypt;
^cApplied Organic Chemistry Department, National Research Centre, Cairo, Dokki, 12622 Egypt;
^dDepartment of Pharmacology, National Research Centre, Cairo, Dokki, 12622 Egypt;
^eCollege of Medicine and Medical Sciences, Taif University, Saudi Arabia

Received February 17, 2014; in final form, July 23, 2014

Some novel bicyclic thiazolopyrimidine derivatives bearing various substituents have been synthesized through one-pot three-component method. Structures of the target compounds were confirmed by elemental analysis and spectral data. Some selected members of the newly synthesized compounds were investigated for their analgesic and anti-inflammatory activities and revealed pronounced anti-inflammatory activity greater than that of indomethacin (reference drug).

Keywords: thiazolopyrimidine, Biginelli compounds, anti-inflammatory, analgesic.

Биоорг. химия 2015, 41(2): 218–226