SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(SUBSTITUTED PHENYL)-2-(5H-[1,2,4]TRIAZINO[5,6-b]INDOL-3-YLSULFANYL)ACETAMIDES AS ANTIMICROBIAL, ANTIDEPRESSANT AND ANTICONVULSANT AGENTS

© 2015 N. Shruthi^a, Boja Poojary^{a, #}, Vasantha Kumar^a, A. Prathibha^a,

Mumtaz Mohammed Hussain^b, B. C. Revanasiddappa^c, and Himanshu Joshi^c

^#Tel./fax: +91-824-2287262/2287367; e-mail: [email protected]

^aDepartment of Chemistry, Mangalore University, Mangalagangothri7574199, Karnataka, India;
^bDepartment of Pharmaceutical Chemistry, S.J.M. College of Pharmacy, Chitradurga7575501, Karnataka, India;
^cDepartment of Pharmacology, N.G.S.M. Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore7575 018, Karnataka, India

Received September 8, 2014; in final form, November 3, 2014

A new series of N-Aryl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides were synthesized by condensation of tricyclic compound 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione with chloro N-phenylacetamides. The tricyclic compound was obtained by condensation of Isatin with thiosemicarbazide. Chloro N-phenylacetamides were obtained from different substituted anilines. Their structures were characterized by IR, ¹H NMR, LC-MS and elemental analyses. Newly synthesized compounds were screened for antimicrobial, antidepressant and anticonvulsant activities. Preliminary results indicated that most of the compounds showed lesser MIC value than the standard drug used when tested for antimicrobial activity. Some of the compounds were endowed with very good antidepressant and anticonvulsant activity.

Keywords: [1,2,4]triazino[5,6-b]indoles, antimicrobial activities, antidepressant activities, anticonvulsant activities.

Биоорг. химия 2015, 41(2): 249–256