NOVEL 3-PYRIDINECARBONITRILE INCORPORATING SULFONAMIDE MOIETIES AS ANTI-BREAST CANCER AGENTS

© 2016 Mostafa M. Ghorab*^, **^{, #} and Mansour S. Alsaid*

^#Phone: +966 534292860; fax: +966 01 4670560; e-mail: [email protected]

*Pharmacognosy Department, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451 Saudi Arabia;
**Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, 113701 Egypt

Received January 25, 2016; in final form, February 10, 2016

A novel series of 3-pyridinecarbonitrile derivatives incorporating sulfonamide moieties and sulfonyl derivatives was synthesized using 2-chloro-6-methylnicotinonitrile as a strategic starting material. The structures of the synthesized compounds were elucidated on the basis of elemental analysis, IR, ¹H NMR, ¹³C NMR, and mass spectral data. All the prepared compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF-7). Most of the compounds showed good to moderate activity, higher than that of the reference drug doxorubicin. Two compounds showed the same activity as doxorubicin, while three compounds exhibited remarkable activity.

Keywords: synthesis, 3-pyridinecarbonitrile, sulfonamide, anti-breast cancer activity.

Биоорг. химия 2016, 42 (4): 488-495