Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity

Prakash L. Kalavadiya, Vimal H. Kapupara, Dinesh G. Gojiya, Tejal D. Bhatt, Sanjay D. Hadiyal and Dr. Hitendra S. Joshi¹

¹E-mail: [email protected]

Department of Chemistry, Saurashtra University, Rajkot-360005, Gujrat, India

Received 23.12.2019; revised 11.03.2020; accepted 19.03.2020

DOI: 10.1134/S1068162020050106

Abstract––In the presents work synthesis and characterization of new heterocyclic derivatives containing pyrazolo[3,4-d]pyrimidine linkage with 1,4-disubstituted-1,2,3-triazoles via methylene-oxy group. The selected synthesized compounds were tested for their in-vitro anticancer activity against various cancer cell lines. Synthesis of compounds was done under ultrasonic-assisted Huisgen 1,3-dipolar cycloaddition reaction with good yields. Some of the newly synthesized compounds demonstrated good to moderate anticancer activity, most of compounds shows activity against renal cancer cell lines.

Keywords: Pyrazolo[3,4-d]pyrimidin-4-ol, 1,4-Disubstituted-1,2,3-triazole derivatives, In-vitro anticancer screening, Ultrasonic-assisted mild reaction conditions
________________________
Полный текст статьи печатается в переводной версии журнала Russian Journal of Bioorganic Chemistry, V.46, Issue 5, P. 803–813 (Springer).