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MODIFICATION OF HAEMOGLOBIN BY GLUTARIC ALDEHYDE AND INVESTIGATION OF ELECTROCHEMICAL PROPERTIES OF RESULTING CONJUGATES
KUZNETSOVA N. P., GUDKIN L. R., SAMSONOV G. V.
Institute of Macromolecular Compounds, Academy of Sciences of the USSR, Leningrad
Abstract: Electrochemical properties of macromolecules of modified haemoglobin obtained by polycondensation with glutaric aldehyde have been investigated by means of potentio-metric titration, PAG-electrophoresis, ion-exchange chromatography, and (for evaluation of isoelectric point) distribution between two aqueous polymeric phases. Introduction of additional functional groups into the macromolecule is possible by using various agents blocking polycondensation, which makes it possible to change the resulting charge and the isoelectric point.
Russian Journal of Bioorganic Chemistry 1990, 16 (1):41-46