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Compounds related to acyclovir. VII. An approach to designing an antiherpetic agent (6-hydroxy-2-oxahexen-4-yl derivative of nucleic bases)
S. V. Kochetkova, T. L. Tsilevich, G. V. Vladyko, L. V. Korobchenko, E. I. Boreko, I. P. Smirnov, A. A. Khorlin, B. P. Gottikh, V. L. Florentiev
V. A. Engelhardt Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow; Institute of Epidemiology and Microbiology, Health Ministry of the Byelorussian SSR, Minsk
Abstract: Based on the available data on the acyclovir's mechanism of action we attempted to predict the antiherpetic activity of 6-hydroxy-2-oxahexen-4-yl derivatives of nucleic bases. In terms of this model 9-(6-hydroxy-2-oxahexen-4-yl) guanine might be active. 6-Hydroxy-2-oxahexen-4-yl derivatives of adenine, guanine, cytosine, thymine, uracile, 1,2,4-triazole-3 and 1,2,4-triazole-5-carboxamide have been synthesized and their activity against herpes virus I investigated. The guanine derivative proved to possess rather high activity (chemotherapeutical index 8).
Russian Journal of Bioorganic Chemistry 1990, 16 (10):1362-1368