Synthetic immunogenic complexes containing a peptide from the surface protein of the foot-and-mouth disease virus

V. A. Rar, E. A. Makarov, V. V. Yurovsky, E. A. Meshcheryakova, T. M. Andronova, V. T. Ivanov

M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow; Branch of M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Pushchino

Abstract: Synthetic constructions containing a peptide antigenic determinant (C-terminal peptide 205–213of the surface VP₁ protein of the foot-and-mouth disease virus, O₁K strain), glucosaminylmuramayl dipeptide (GMDP), and poly ionic synthetic carriers were prepared. The polymerized peptide and peptide-BSA conjugates were synthesized as well. Among the constructions obtained only peptide-BSA conjugate proved to be highly immunogenic. Application of synthetic constructions to design immunogenic complexes is discussed.

Russian Journal of Bioorganic Chemistry 1990, 16 (7):904-915

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