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The synthesis of 4,5-dehydrodocosahexaenoic and 5,6-dehydroeicosapentaenoic acids and their selectively tritium labeled derivatives
D. V. Kuklev, V. P. Shevchenko, I. Yu. Nagaev, N.A. Latyshev, V. V. Bezuglov
M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR,
Moscow
Abstract: 4,5-Dehydrodocosahexaenois and 5,6-dehydroeicosapentaenoic acids have been synthesized from the corresponding natural fatty acids. The obtained acetylenic fatty acids have been used for producing selectively radiolabelled derivatives of docosahexaenoic and eicosapentaenoic acids with the natural configuration of the double bonds and the molar radioactivity of 1,5–1,8 PBq/mol. Formation of allenic structures and bromo lac-tones as by-products in the synthesis is described.
Russian Journal of Bioorganic Chemistry 1991, 17 (11):1574-1581