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Synaptosomal degradation of neuropeptides
T. N. Akopyan, A. M. Arzumanyan, A. G. Aghajanyan, A. A. Arutyunyan
Institute of Experimental Biology, Academy of Sciences, Republic of Armenia, Yerevan
Abstract: Proteolytic conversions of some neuropeptides possessing neurotransmitter and neu-romodulator properties were studied on the synaptosomal plasma membrane level. The main goal was to describe the peptide bonds being primarily hydrolysed by membrane peptidases. The analysis of the accumulated data allowed one to make some summarizing conclutions about properties of the enzyme system responsible for the biological inactivation of the peptides in synapsis.
Russian Journal of Bioorganic Chemistry 1991, 17 (12):1589-1604