 |  |
The synthesis of β-mannosides by glycosylation of α-mannosyl thiocyanates
E. M. Klimov, A. V. Demchenko, N. N. Malysheva, N. K. Kochetkov
N. D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow
Abstract: A new method of the trityl-thiooyanathe condensation is used for synthesizing low availabe β-D-mannopyranosyl-hexoses. α-D-Mannopyranosyl thiocyanates with a non-participating group (OMe, OCOCCl3) at C-2 react with the 6-O-trityl-D-glucose and 4-O-trityl-L-rhamnose derivatives in the presence of triphenylmethilium perchlorate to give mixtures of α- and β-linked disaccharides with satisfactory yields.
Russian Journal of Bioorganic Chemistry 1991, 17 (12):1660-1664