Antigenic structure of the foot-and-mouth disease virus. VI. Functional sites of the immunodominant region of VP₁ protein of the foot-and-mouth disease virus O₁K and A₂₂ strains

V. M. Gel'fanov, L. A. Grechaninova, E. S. Kan, A. V. Yarov, A. Yu. Surovoy, O. M. Vol'pina, A. V. Chepurkin, V. T. Ivanov

M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow

Abstract: B- and T-epitopes have been localized within the protective fragments of VP₁ protein, viz., 136–152 of the O₁K strain and 135–159 of the A₂₂ strain of the foot-and-mouth disease virus (FMDV). Antibodies eliciting after immunization of various animals with the 135–159 A₂₂ peptide are directed to different sites of the peptide. Immunogenicity of fragments of the 135–159 A₂₂ peptide on mice correlates with their activity on T-cells of the same animals and protective activity on guinea pigs. The investigations were carried out using synthetic fragments of the 136–152-O₁K and 135–159-A₂₂ peptides.

Russian Journal of Bioorganic Chemistry 1991, 17 (5):596-605

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